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Its latest releases include Wolves, a 5-reel video slot with a healthy RTP and  [http://120.zsluoping.cn/home.php?mod=space&uid=1261092 프라그마틱 사이트] stunning graphics. Other notable games include Wolf Gold and Chilli Heat.<br><br>The purpose of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to determine the causality of an intervention and its effects. However, they should not, be used to replace the need for explanation studies.<br><br>The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they are an addition to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the elements of a practical study which includes the recruitment, design, and delivery of the intervention and its follow-up.<br><br>There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind, however, that the majority of these studies were conducted in primary-care settings.