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Wolves is one of the latest games, a 5-reel slot machine with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.<br><br>The aim of pragmatic trials is to replicate real-life scenarios and gain maximum validity externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They can also be a great method to determine the causal relationship between an intervention and its outcomes. However, they should not be used to substitute for explanation trials.<br><br>The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for  [http://promarket.in.ua/user/formchick8/ 프라그마틱 정품인증] 무료체험 메타 - [https://images.google.com.na/url?q=https://blogfreely.net/beltdesire6/14-questions-you-might-be-refused-to-ask-pragmatic-kr read this post from Google], pragmatic trials.2 This tool tried to define the characteristics of a practical study that includes the recruitment, design, and delivery of the intervention, and follow-up.<br><br>There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health science community is becoming more sensitive to the subject of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary-care settings.