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The latest releases include Wolves which is a five-reel video slot with a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.<br><br>Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are typically commissioned by policymakers and  [https://intern.ee.aeust.edu.tw/home.php?mod=space&uid=537024 프라그마틱 공식홈페이지] practitioners to guide their decisions. They can also be used to assess the cause-effect relationship of an intervention with its outcomes. They should, however, not, be used to replace the need for explanation studies.<br><br>The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the traits of a practical study that includes recruitment, design, implementation of the intervention and its follow-up.<br><br>There is a growing increase in the number pragmatic trials that have been published. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind that the majority were conducted in primary-care settings.