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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are often characterized by a focus on practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and included participants from different geographical regions. This type of heterogeneity is essential for practical trials to be valid and helps to reduce the chance of bias in the results. However, too much heterogeneity, can cause problems with the trial design.

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Pragmatic Play offers a large variety of games you can play for free before you decide whether or not to purchase them. The games for free are designed to work on all types of devices from tablets to desktops and smartphones. You can play them wherever you have an internet connection. They are easy to navigate. Some Pragmatic Play websites even let you test your luck while in motion by playing a test mode. This will allow you to get familiar with the game's rules and features before playing for real money.

Legality

Pragmatic Play is known for its top-quality games and also for providing an outstanding user experience. Its software is designed to work with mobile devices and is compatible with various languages. Despite its relatively young age it has already established itself as a leading casino gaming platform. The most recent releases include Wolves which is a five-reel video slot that has a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. Usually, they are commissioned by policymakers and practitioners to guide their decisions. They can also be used to assess the causality of an intervention with its outcomes. However, they should not be used as a substitute for explanatory studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can be used to replace explanation tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study, including recruitment, design, delivery of the intervention and follow-up.

There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.