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Peritoneal Mesothelioma Asbestos Symptoms<br><br>Peritoneal mesothelioma asbestos symptoms typically affect the digestive system. This is due to asbestos fibers being ingested, and become embedded in the lining of the stomach known as the peritoneum.<br><br>Over time, these fibres result in mutations to the healthy peritoneal cells. Tumors that are cancerous develop in the peritoneum as a result.<br><br>Mesothelioma is a difficult disease to diagnose. The initial signs may resemble symptoms of other conditions, like hernia or irritable bowel syndrome.<br><br>Signs and symptoms<br><br>Asbestos fibers can travel through the body when inhaled. They can then be stuck in the abdominal lining or other organs, creating inflammation and irritation that can lead to tumor growth. The process can take years to develop, and many victims are unaware of their asbestos exposure until it is too late.<br><br>Asbestos fibers may get caught in the tissue lining the abdominal cavity, or other organs, causing malignant peritoneal melanomas. It is the second most common mesothelioma type. However it can be difficult for doctors to recognize as early symptoms are nonspecific. They may also be similar to gastrointestinal conditions. Patients with peritoneal mesothelioma often experience stomach pain, fatigue and gastrointestinal problems.<br><br>Mesothelioma patients are usually diagnosed with peritoneal mesothelioma after conducting a physical examination and a medical history review and an array of laboratory tests. A X-ray as well as a CT scan can assist doctors to find any lumps or symptoms of disease. In some instances mesothelioma physicians may require a biopsy to get an precise diagnosis.<br><br>Peritoneal Mesothelioma Symptoms usually begin in the abdomen. They can cause extreme abdominal discomfort, bloating, and weight loss. They may also cause nausea, vomiting, and other digestive issues. Other symptoms include fatigue, chest pain and swelling. If these symptoms are present it is essential to seek medical attention as they could be triggered by other ailments.<br><br>Despite the difficulty of diagnosing patients with peritoneal msothelioma, they can often be treated to prolong their lives. In the majority of cases, this is done through the use of surgery and chemotherapy that is heated.<br><br>If you or a loved one have been diagnosed with peritoneal mesothelioma, call our [https://jszst.com.cn/home.php?mod=space&uid=4209420 mesothelioma lawyers], [https://doodleordie.com/profile/hailton71 simply click the up coming website], to learn more about what we can do to help. We can help you connect with mesothelioma specialists in your area who can assist you in bringing a lawsuit against the asbestos-related companies responsible for your exposure. We can also ensure you receive the financial settlement you deserve. You can start this process by filling out our no-cost online form. We can assist you to get the best possible outcome by working with the best mesothelioma lawyers.<br><br>Diagnosis<br><br>The first step in identifying mesothelioma of the peritoneal region is to collect an exact medical history. Doctors will ask about the person's exposure asbestos and the time it occurred. A physical examination will be conducted. X-rays, blood tests and CT scans are often employed in the initial examination.<br><br>Peritoneal mesothelioma is difficult to identify due to its long period of latency. Patients might experience symptoms such as nausea, abdominal pain, and fever that are similar to those of other conditions. These nonspecific symptoms can cause confusion for doctors. Mesothelioma is a rare cancer that can take years to show symptoms after asbestos exposure, is a rare disease.<br><br>Asbestos fibers that are inhaled or consumed travel to the stomach lining, known as the peritoneum. Asbestos fibers that are sharp can irritate mesothelium after they reach the peritoneum. In time this irritation can cause inflammation and scar tissue. This leads to abnormal cell proliferation and tumors.<br><br>Researchers are working to develop ways to detect the disease in its earliest stages. The stage of mesothelioma will determine the treatment options.<br><br>A mesothelioma expert can perform paracentesis (percutaneous needle biopsy) to collect a sample for laboratory testing. These tests can help identify the type of cancer cells (epithelioid or sarcomatoid) within the tumor and help doctors determine the best treatment plan.<br><br>Mesothelioma specialists can also assess a patient's stage of mesothelioma. The stage determines the most effective treatment and helps mesothelioma lawyers know which asbestos-related companies are responsible in mesothelioma cases.<br><br>If a mesothelioma specialist analyzes the results of a biopsy and creates a pathology report that contains information on the type mesothelioma. The report could also include a staging system that describes how the cancer has spread throughout the body. The more advanced the stage of cancer is, the less likely the patient will be able to respond to treatment. A lawyer can explain the implications of this for the particular case of a client.<br><br>Treatment<br><br>Asbestos fibers can be breathed in or consumed and are absorbed in the tissues lining the abdomen and other organs. They damage DNA and irritate cells. As time passes, this leads to the development of tumors in the lining. The majority of the time, peritoneal cancer develops in the lining of the abdomen. Peritoneal Mesothelioma affects more women than pleural Mesothelioma but it is less common.<br><br>Symptoms of peritoneal mesothelioma are similar to symptoms of gastrointestinal disorders such as irritable bowel syndrome and Crohn's disease, making it difficult for doctors to diagnose the condition. Because of this, early symptoms can be mistaken as normal ailments, and can last for months or years before a patient is given a mesothelioma diagnosis.<br><br>A doctor may also perform tests of blood and imaging to rule out any other diseases or conditions that could trigger the same symptoms as mesothelioma. These tests can also be used to determine the best treatment options.<br><br>Because peritoneal mesothelioma develops in the abdominal lining A doctor will conduct biopsy to confirm a diagnosis. A biopsy is the removal of small samples from the affected area to be examined by pathologists. Biopsies can detect cancerous cells and identify the type of mesothelioma.<br><br>Once a peritoneal mesothelioma diagnosis has been confirmed, doctors will discuss options for treatment with the patient. Generally speaking, the aim of a treatment plan is to decrease the size and amount of tumors. Surgery is usually the first option, however patients may also consider chemotherapy and immunotherapy.<br><br>In contrast to the chest-based treatment for pleural mesothelioma which is administered through the lungs, peritoneal Mesothelioma treatment is injected via intravenously or orally. Chemotherapies that are injected, such as heated intraperitoneal chemotherapy (HIPEC) have been able to prolong the life of many patients. HIPEC was invented by mesothelioma expert Paul Sugarbaker.<br><br>Individuals diagnosed with peritoneal mesothelioma may qualify to bring a lawsuit against negligent asbestos companies. A [http://120.zsluoping.cn/home.php?mod=space&uid=1271690 mesothelioma lawyer] can evaluate the case of a patient and suggest legal options. Contact us today to get started. It's completely absolutely free, and confidential, and there is no obligation. We offer nationwide representation.<br><br>Prognosis<br><br>Mesothelioma cancer is rare. Because doctors aren't experienced in diagnosing patients, many are mistakenly diagnosed with other illnesses. A mesothelioma expert can help patients identify the cause and ensure that they receive the right treatment.<br><br>Asbestos exposure is only the one known cause of peritoneal mesothelioma. When asbestos fibers are inhaled or ingested, they could cause irritation to abdominal tissues and cause cells to change. This can lead to tumors that develop into mesothelioma in the peritoneum over time.<br><br>The exposure to asbestos usually is a result of jobs in manufacturing or construction. These industries may use materials that contain asbestos, like insulation and fireproofing. Asbestos is also present in household products, such as roof tiles and flooring. Even the smallest amount of asbestos exposure can put a person in danger of developing mesothelioma. Because of the long time of latency the victims could be diagnosed with peritoneal [https://mozillabd.science/wiki/Brittcarson1157 mesothelioma lawsuit] for a long time after their initial exposure.<br><br>Peritoneal Mesothelioma can mimic other conditions. It is often mistaken for hernias, gastrointestinal problems like Crohn's or colitis, and other types of abdominal cancer. A lot of patients do not disclose their asbestos exposure, and do not seek medical care. If mesothelioma is found, the specialists may recommend a biopsy for a more accurate diagnosis. A biopsy involves the removal of tiny pieces of tissue to be examined. This procedure will reveal the stage of mesothelioma and whether it is epithelioid biphasic or sarcomatoid.<br><br>If mesothelioma has not spread, doctors can remove the tumors. They can also provide a curative treatment. The specialist can also determine if the cancer has been able to spread to the abdomen. They may then recommend palliative care for the patient, such as paracentesis, which drains the abdominal fluid.<br><br>When a mesothelioma is advanced and the prognosis is less favorable, it becomes more difficult to treat. The tumors could become resistant to certain treatments and recur. The specialist may recommend an amalgamation of surgery and chemotherapy. Options for surgery include cytoreduction and hyperthermic intraperitoneal chemo. This combination is more likely than chemotherapy alone to improve the prognosis for a patient.
Peritoneal Mesothelioma Asbestos Symptoms<br><br>The digestive system is often affected by the symptoms of mesothelioma of the peritoneal region. This is because asbestos fibers are ingested and become embedded in the stomach's lining, called the peritoneum.<br><br>Over time, these fibers cause mutations in healthy peritoneal cells. In the end, cancerous tumors form in the peritoneum.<br><br>Mesothelioma is a challenging condition to identify. The initial signs may resemble symptoms of other diseases, like hernia or IBS.<br><br>Symptoms<br><br>When asbestos fibers are breathed in, they can be absorbed into the lungs and then travel throughout the body. The fibers can then get trapped in the linings of the abdomen and other organs. This causes irritation and inflammation, which results in the development of tumors. This process can take a long time to develop, and most victims are unaware that they are exposed to [https://willysforsale.com/author/taxidoubt65/ asbestos settlement] until it is too late.<br><br>Malignant peritoneal mesothelioma is a condition that occurs asbestos fibers are trapped in the tissues that line the abdominal cavity and other organs. It is the second most frequent mesothelioma type, however it is difficult to recognize because the early symptoms are not specific and similar to those of gastrointestinal disorders. Patients with peritoneal cancer often have stomach pain, fatigue and gastrointestinal issues.<br><br>After a physical examination followed by a review of medical history and a series tests in the laboratory, mesothelioma patients are diagnosed with peritoneal cancer. A CT scan or X-ray may help doctors identify lumps, or other indications of illness. In some instances mesothelioma physicians may require a biopsy to get a more accurate diagnosis.<br><br>Peritoneal mesothelioma symptoms usually begin in the abdomen and can result in extreme abdominal discomfort, weight loss, bloating stomach fluid accumulation nausea, vomiting, and other digestive issues. Other symptoms include chest pain, fatigue and swelling. When these symptoms occur it is essential that patients seek medical attention as they could be triggered by other conditions.<br><br>Despite the difficulty in diagnosing peritoneal msothelioma patients can often be treated to prolong their lives. In the majority of cases, the treatment involves surgery and heated chemo.<br><br>Contact our mesothelioma lawyers today to learn more about how we can help you if someone in your family has been diagnosed with peritoneal msothelioma. We can help you locate an expert in mesothelioma near you who can help you file an [https://www.alonegocio.net.br/author/womenpyjama95/ asbestos lawsuit] against the companies that are responsible for your exposure. We can also assist you in ensuring that you receive the financial compensation that you deserve. Complete our online form to begin the process. We can assist you in obtaining the best possible outcome working with the top mesothelioma lawyers.<br><br>Diagnosis<br><br>The first step in identifying mesothelioma peritoneal is to obtain an accurate medical history. Doctors will inquire about the patient's exposure to asbestos and when it occurred. They may also conduct a physical examination. Blood tests, X-rays and CT scans are commonly utilized in the initial check-up.<br><br>Because of the long period of latency, peritoneal mesothelioma is often difficult to identify. Patients may experience symptoms such as abdominal pain, fever and nausea that are similar to other conditions. These non-specific symptoms can confuse doctors. Mesothelioma is a rare type of cancer that can take decades for symptoms to manifest after asbestos exposure.<br><br>Inhaling or eating asbestos fibers travel into the stomach lining, known as the peritoneum. When they reach the peritoneum, the sharp asbestos fibers irritate the mesothelium. This irritation can cause inflammation and scar tissue over time. This causes abnormal cell growth and tumors.<br><br>Researchers are working to develop methods to detect mesothelioma early. The stage of mesothelioma will determine the treatment options.<br><br>A mesothelioma specialist may perform paracentesis (percutaneous needle biopsy) to collect a sample for laboratory testing. These tests will reveal if the cancerous cells are epithelioid (epithelioid), Sarcomatoid (sarcomatoid) or biphasic within the tumor. This information helps doctors create an appropriate treatment plan.<br><br>Specialists in mesothelioma can also determine the stage of a patient. The staging process determines which treatments will be most effective and helps mesothelioma attorneys know which asbestos-related companies to sue in mesothelioma lawsuits.<br><br>When a mesothelioma expert reviews the results of a biopsy and creates a pathology report that includes information about the type of mesothelioma. The report may also include an assessment scale that reveals how the cancer has spread within the body. The more advanced the stage of cancer, the less likely the patient will respond to treatment. A lawyer can explain the implications of this to specific clients.<br><br>Treatment<br><br>Asbestos fibers can be inhaled or ingested and become embedded in the tissue lining the abdomen and other organs. They damage DNA and can cause irritation to cells. This can lead to the development of tumors. Typically, peritoneal mesothelioma develops in the lining of the abdomen called the peritoneum. Peritoneal mesothelioma occurs less frequently than pleural mesothelioma. It usually affects women more.<br><br>The symptoms of peritoneal cancer are similar to those seen with gastrointestinal disorders, such as Crohn's disease and irritable bowel syndrome which makes it difficult for doctors to identify. Early symptoms can be mistaken for other ailments and can last for a long time, or even years before mesothelioma diagnosis is made.<br><br>A doctor may also perform imaging and blood tests to rule out any other diseases or conditions that could trigger mesothelioma-like symptoms. These tests can aid in determining the most effective treatment options.<br><br>Since peritoneal mesothelioma can develop in the abdominal lining A doctor will conduct a biopsy to confirm a diagnosis. A biopsy is the process of removing small amounts of the affected area to be examined by pathologists. Biopsies can reveal cancerous cells, and determine the type of Mesothelioma.<br><br>After a peritoneal msothelioma is confirmed doctors will discuss treatment options with patients. The aim of any treatment plan is generally to reduce the size and quantity of tumors. Surgery is often the first option, but patients may also consider chemotherapy and immunotherapy.<br><br>In contrast to the chest-based treatment for pleural mesothelioma which is administered through the lungs, the treatment for peritoneal Mesothelioma is administered either intravenously or orally. Chemotherapies that are injected, such as heated intraperitoneal chemotherapy (HIPEC) have been able to prolong the lives of many patients. HIPEC is a method that was invented by mesothelioma pioneer Paul Sugarbaker.<br><br>Individuals diagnosed with peritoneal mesothelioma may be eligible to bring an [https://willysforsale.com/author/dresslocket7/ asbestos] lawsuit ([https://arealarch31.bravejournal.net/24-hours-to-improve-asbestos-mesothelioma-cancer arealarch31.Bravejournal.Net]) against negligent companies. A knowledgeable mesothelioma attorney will review the case of a patient and recommend legal options. Contact us today to get started. Contact us today. It's free, confidential and there's absolutely no obligation. We provide nationwide representation.<br><br>Prognosis<br><br>Mesothelioma is a rare type of cancer. Doctors have limited experience with it, and many patients are misdiagnosed as having other illnesses. Fortunately mesothelioma specialists can help with the diagnostic process and get patients the appropriate treatment.<br><br>[https://coughleaf4.werite.net/the-top-asbestos-and-peritoneal-mesothelioma-gurus-are-doing-three-things asbestos law] exposure is the sole known cause of peritoneal mesthelioma. When asbestos fibers are inhaled or ingested, they can cause irritation to abdominal tissues and cause cells to alter. As time passes, this could cause tumors to form mesothelioma of peritoneum.<br><br>Manufacturing or construction is usually the first area where asbestos exposure can begin. These industries may use products that contain asbestos, such as insulation and fireproofing. Asbestos is also found in household products such as flooring and roofing tiles. Even the smallest amounts of exposure can put a person at risk of developing mesothelioma. Because mesothelioma has a long latency period, victims can sometimes be diagnosed with peritoneal mesothelioma decades after the initial exposure.<br><br>Peritoneal mesothelioma symptoms may appear similar to other conditions and can be mistaken for a hernia digestive issues such as Crohn's disease or colitis, or other types of abdominal cancer. Many patients don't report their asbestos exposure and do not seek medical attention. If mesothelioma has been identified experts may suggest a biopsy for a more precise diagnosis. A biopsy is the removal the smallest piece of tissue that is examined. This test will reveal whether the mesothelioma has epithelioid (epidermoid), sarcomatoid (sarcomatoid) or biphasic.<br><br>If the mesothelioma is in an early stage, doctors can remove all of the tumors and provide curative treatment. The doctor can also determine whether the cancer has spread within the abdomen. They can then prescribe palliative care for the patient. For instance paracentesis, which is a procedure to drain abdominal fluid.<br><br>The outlook for patients is worse when mesothelioma is advanced. The tumors may become resistant to certain treatments and may recur. The doctor might recommend an amalgamation of surgery and chemotherapy. The surgical options include cytoreduction surgery along with hyperthermic intraperitoneal therapy. This combination is more likely than chemotherapy alone to improve the prognosis of patients.

Revision as of 00:59, 27 November 2024

Peritoneal Mesothelioma Asbestos Symptoms

The digestive system is often affected by the symptoms of mesothelioma of the peritoneal region. This is because asbestos fibers are ingested and become embedded in the stomach's lining, called the peritoneum.

Over time, these fibers cause mutations in healthy peritoneal cells. In the end, cancerous tumors form in the peritoneum.

Mesothelioma is a challenging condition to identify. The initial signs may resemble symptoms of other diseases, like hernia or IBS.

Symptoms

When asbestos fibers are breathed in, they can be absorbed into the lungs and then travel throughout the body. The fibers can then get trapped in the linings of the abdomen and other organs. This causes irritation and inflammation, which results in the development of tumors. This process can take a long time to develop, and most victims are unaware that they are exposed to asbestos settlement until it is too late.

Malignant peritoneal mesothelioma is a condition that occurs asbestos fibers are trapped in the tissues that line the abdominal cavity and other organs. It is the second most frequent mesothelioma type, however it is difficult to recognize because the early symptoms are not specific and similar to those of gastrointestinal disorders. Patients with peritoneal cancer often have stomach pain, fatigue and gastrointestinal issues.

After a physical examination followed by a review of medical history and a series tests in the laboratory, mesothelioma patients are diagnosed with peritoneal cancer. A CT scan or X-ray may help doctors identify lumps, or other indications of illness. In some instances mesothelioma physicians may require a biopsy to get a more accurate diagnosis.

Peritoneal mesothelioma symptoms usually begin in the abdomen and can result in extreme abdominal discomfort, weight loss, bloating stomach fluid accumulation nausea, vomiting, and other digestive issues. Other symptoms include chest pain, fatigue and swelling. When these symptoms occur it is essential that patients seek medical attention as they could be triggered by other conditions.

Despite the difficulty in diagnosing peritoneal msothelioma patients can often be treated to prolong their lives. In the majority of cases, the treatment involves surgery and heated chemo.

Contact our mesothelioma lawyers today to learn more about how we can help you if someone in your family has been diagnosed with peritoneal msothelioma. We can help you locate an expert in mesothelioma near you who can help you file an asbestos lawsuit against the companies that are responsible for your exposure. We can also assist you in ensuring that you receive the financial compensation that you deserve. Complete our online form to begin the process. We can assist you in obtaining the best possible outcome working with the top mesothelioma lawyers.

Diagnosis

The first step in identifying mesothelioma peritoneal is to obtain an accurate medical history. Doctors will inquire about the patient's exposure to asbestos and when it occurred. They may also conduct a physical examination. Blood tests, X-rays and CT scans are commonly utilized in the initial check-up.

Because of the long period of latency, peritoneal mesothelioma is often difficult to identify. Patients may experience symptoms such as abdominal pain, fever and nausea that are similar to other conditions. These non-specific symptoms can confuse doctors. Mesothelioma is a rare type of cancer that can take decades for symptoms to manifest after asbestos exposure.

Inhaling or eating asbestos fibers travel into the stomach lining, known as the peritoneum. When they reach the peritoneum, the sharp asbestos fibers irritate the mesothelium. This irritation can cause inflammation and scar tissue over time. This causes abnormal cell growth and tumors.

Researchers are working to develop methods to detect mesothelioma early. The stage of mesothelioma will determine the treatment options.

A mesothelioma specialist may perform paracentesis (percutaneous needle biopsy) to collect a sample for laboratory testing. These tests will reveal if the cancerous cells are epithelioid (epithelioid), Sarcomatoid (sarcomatoid) or biphasic within the tumor. This information helps doctors create an appropriate treatment plan.

Specialists in mesothelioma can also determine the stage of a patient. The staging process determines which treatments will be most effective and helps mesothelioma attorneys know which asbestos-related companies to sue in mesothelioma lawsuits.

When a mesothelioma expert reviews the results of a biopsy and creates a pathology report that includes information about the type of mesothelioma. The report may also include an assessment scale that reveals how the cancer has spread within the body. The more advanced the stage of cancer, the less likely the patient will respond to treatment. A lawyer can explain the implications of this to specific clients.

Treatment

Asbestos fibers can be inhaled or ingested and become embedded in the tissue lining the abdomen and other organs. They damage DNA and can cause irritation to cells. This can lead to the development of tumors. Typically, peritoneal mesothelioma develops in the lining of the abdomen called the peritoneum. Peritoneal mesothelioma occurs less frequently than pleural mesothelioma. It usually affects women more.

The symptoms of peritoneal cancer are similar to those seen with gastrointestinal disorders, such as Crohn's disease and irritable bowel syndrome which makes it difficult for doctors to identify. Early symptoms can be mistaken for other ailments and can last for a long time, or even years before mesothelioma diagnosis is made.

A doctor may also perform imaging and blood tests to rule out any other diseases or conditions that could trigger mesothelioma-like symptoms. These tests can aid in determining the most effective treatment options.

Since peritoneal mesothelioma can develop in the abdominal lining A doctor will conduct a biopsy to confirm a diagnosis. A biopsy is the process of removing small amounts of the affected area to be examined by pathologists. Biopsies can reveal cancerous cells, and determine the type of Mesothelioma.

After a peritoneal msothelioma is confirmed doctors will discuss treatment options with patients. The aim of any treatment plan is generally to reduce the size and quantity of tumors. Surgery is often the first option, but patients may also consider chemotherapy and immunotherapy.

In contrast to the chest-based treatment for pleural mesothelioma which is administered through the lungs, the treatment for peritoneal Mesothelioma is administered either intravenously or orally. Chemotherapies that are injected, such as heated intraperitoneal chemotherapy (HIPEC) have been able to prolong the lives of many patients. HIPEC is a method that was invented by mesothelioma pioneer Paul Sugarbaker.

Individuals diagnosed with peritoneal mesothelioma may be eligible to bring an asbestos lawsuit (arealarch31.Bravejournal.Net) against negligent companies. A knowledgeable mesothelioma attorney will review the case of a patient and recommend legal options. Contact us today to get started. Contact us today. It's free, confidential and there's absolutely no obligation. We provide nationwide representation.

Prognosis

Mesothelioma is a rare type of cancer. Doctors have limited experience with it, and many patients are misdiagnosed as having other illnesses. Fortunately mesothelioma specialists can help with the diagnostic process and get patients the appropriate treatment.

asbestos law exposure is the sole known cause of peritoneal mesthelioma. When asbestos fibers are inhaled or ingested, they can cause irritation to abdominal tissues and cause cells to alter. As time passes, this could cause tumors to form mesothelioma of peritoneum.

Manufacturing or construction is usually the first area where asbestos exposure can begin. These industries may use products that contain asbestos, such as insulation and fireproofing. Asbestos is also found in household products such as flooring and roofing tiles. Even the smallest amounts of exposure can put a person at risk of developing mesothelioma. Because mesothelioma has a long latency period, victims can sometimes be diagnosed with peritoneal mesothelioma decades after the initial exposure.

Peritoneal mesothelioma symptoms may appear similar to other conditions and can be mistaken for a hernia digestive issues such as Crohn's disease or colitis, or other types of abdominal cancer. Many patients don't report their asbestos exposure and do not seek medical attention. If mesothelioma has been identified experts may suggest a biopsy for a more precise diagnosis. A biopsy is the removal the smallest piece of tissue that is examined. This test will reveal whether the mesothelioma has epithelioid (epidermoid), sarcomatoid (sarcomatoid) or biphasic.

If the mesothelioma is in an early stage, doctors can remove all of the tumors and provide curative treatment. The doctor can also determine whether the cancer has spread within the abdomen. They can then prescribe palliative care for the patient. For instance paracentesis, which is a procedure to drain abdominal fluid.

The outlook for patients is worse when mesothelioma is advanced. The tumors may become resistant to certain treatments and may recur. The doctor might recommend an amalgamation of surgery and chemotherapy. The surgical options include cytoreduction surgery along with hyperthermic intraperitoneal therapy. This combination is more likely than chemotherapy alone to improve the prognosis of patients.