10 Pragmatic Free Trial Tricks Experts Recommend

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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are often characterized by their focus on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographic areas. This type of heterogeneity is essential for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. However, too much heterogeneity can result in problems with the trial design.

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Mobile compatibility

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Legality

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The goal of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. Usually, they are requested by practitioners and policymakers in order to guide their decisions. They can be used to determine the causality of an intervention with its outcomes. They should not, however be used to replace explanatory studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a practical trial, including the recruitment process, the design and delivery of the intervention, and follow-up.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.