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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of standard equipment.
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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid, and it also reduces the chance of bias in the results. A high degree of heterogeneity, however, can cause problems with the trial design.
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The goal of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They also provide a useful method to determine the causality between an intervention and its outcomes. However, they should not be used as a substitute for explanation trials.
The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, 프라그마틱 홈페이지 which confirm the clinical or physiological hypothesis, and pragmatic trials, which guide the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic research study which includes recruitment, design, implementation of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.