10 Pragmatic Free Trial Tricks All Experts Recommend
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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often focused on practical aspects of the study design, such as the recruitment and consent process, adherence, and the use of standard equipment.
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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for practical trials to be valid and also helps to reduce the chance of bias in the results. Too much heterogeneity, however, can cause problems with the design of the trial.
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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually commissioned by practitioners and policy makers to inform their decision making. They also provide a useful method to determine the causality between an intervention and its results. They should, however, not, be used to replace the need for explanation studies.
The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials, which guide the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study which includes recruitment, 프라그마틱 체험 design, implementation of the intervention and its follow-up.
There is an encouraging increase in the number pragmatic trials published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.