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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are typically described as a focus on the practical aspects of designing a study that include the recruitment process and consent, adhering and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from different geographical regions. This type of heterogeneity is required for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. However excessive heterogeneity could lead to issues with the design of the trial.
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Legality
Pragmatic Play has earned a reputation for providing high-quality games and a superior user experience. Its software is designed to work on mobile devices and is compatible with various languages. It has been recognized as one of the leading gaming platforms in the casino industry despite its relative youth. The most recent releases include Wolves, a 5-reel video slot with a healthy RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are typically ordered by policymakers and practitioners to inform their decisions. They can be used to determine the causal relationship between an intervention with its outcomes. They should, however, not be used to replace explanatory studies.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they are a complement to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a practical study, including recruitment, design, implementation of the intervention and follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health science community is becoming more acquaint to the issue of pragmatics. It is important to remember, however, that the majority of studies were conducted in primary-care settings.