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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are typically focused on the practical aspects of the study design, including the recruitment and 프라그마틱 정품확인 consent process in adherence, as well as the use of routinely available equipment.
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A practical trial that employs various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be valid, and it also reduces bias in the results. Too much heterogeneity, however could cause issues with the design of the trial.
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The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are usually requested by policy makers and practitioners to guide their decision-making. They are also a good method to determine the causal relationship between an intervention and its results. However, they should not, be used to replace the need for explanation studies.
The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a practical study that includes the recruitment, design, and delivery of the intervention and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the subject of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.