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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often characterized by a focus on the practical aspects of the study design, such as the recruitment and consent process in adherence, as well as the use of commonly available equipment.
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A pragmatic trial that uses various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for pragmatic trials to be valid and reduce bias in results, is also necessary. A high degree of heterogeneity, however, can cause problems with the design of the trial.
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The aim of pragmatic trials is to replicate real-life scenarios and 프라그마틱 슬롯 환수율 [click through the following page] to achieve the highest level of validity externally. They are typically ordered by policymakers and practitioners in order to inform their decisions. They can also be used to assess the causality of an intervention with its outcomes. However, they shouldn't be used in lieu for explanatory studies.
The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic research study, including the recruitment, design, and delivery of the intervention and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind, however, that the majority of studies were conducted in primary care settings.