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Pragmatic trials are studies designed to provide information for the real-world practice of clinical. They are often characterized by their focus on practical aspects of design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Pragmatic is a software company, offers a variety of casino games to online gambling platforms. Pragmatic's iGaming solutions are used by the most reputable operators as well as land-based casinos. The company offers front-end design tools, analysis tools, promotions, marketing, payment systems, security, customer service, and bug reporting. Additionally, the company offers its players a secure environment that features high-quality graphics and gameplay.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and participants from different geographic areas. This type of heterogeneity is necessary for practical trials to be valid, and it also reduces the chance of bias in the results. However excessive heterogeneity could result in problems with the design of the trial.
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Pragmatic Play is known for its top-notch games, and for offering an exceptional user experience. Its software is designed to work with mobile devices and supports different languages. Despite its relative youth it has established itself as a premier gaming platform for casinos. Wolves is one of the latest games that is a 5-reel slot machine that has a high RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.
Pragmatic trials aim to mimic real-world situations and have the highest external validity. Usually, they are ordered by policymakers and practitioners in order to guide their decisions. They are also a good way to identify the causal relationship between an intervention and its results. They should not, however be used to replace explanatory studies.
The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis and pragmatic trials that inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study that includes recruitment, design, implementation of the intervention, and follow-up.
There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority were conducted in primary care settings.