Five Pragmatic Free Trial Lessons From The Professionals
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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized as focusing on practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and included participants from various geographical areas. This type of heterogeneity which is essential for a pragmatic trial to be reliable and reduce bias in results, is also necessary. Too much heterogeneity, however can result in problems with the design of the trial.
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Mobile compatibility
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Legality
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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually commissioned by practitioners and policy makers to inform their decision making. They are also a good method of determining the causal relationship between an intervention and its results. They should not, however be used to replace explanatory studies.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a pragmatic study that include recruitment, design and delivery of the intervention, and follow-up.
There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, as shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to remember that the majority of these studies were conducted in primary care settings.