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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically described by their focus on practical aspects of study design, including the recruitment process and consent, adhering and the use of routinely available equipment.
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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for practical trials to be valid and also reduces the chance of bias in the results. Too much heterogeneity, however can result in problems with the design of the trial.
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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can also be used to assess the cause-effect relationship of an intervention and its effects. They should, however, not be used to replace explanatory studies.
The pragmatism idea is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials that inform the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study which includes recruitment, design, 프라그마틱 무료체험 슬롯버프 - Https://Www.google.com.pk - implementation of the intervention and its follow-up.
There is an encouraging increase in the number pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, as shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.