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Pragmatic trials are studies designed to inform real-world clinical practice. They are often focused on practical aspects of the study design, such as the recruitment and 라이브 카지노 consent process in adherence, as well as the use of commonly available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from various geographical areas. This kind of heterogeneity is essential for practical trials to be valid and helps reduce bias in the results. However, too much heterogeneity could cause issues with the design of the trial.
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Legality
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The purpose of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are usually commissioned by policymakers and practitioners to inform their decisions. They are also a good method of determining the causal relationship between an intervention and its outcomes. However, they should not be used in lieu for explanation studies.
The concept of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool attempted to define the characteristics of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as follow-up.
There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health science community is becoming more acquaint to the issue of pragmatics. It is important to note, however, that the majority of these studies were conducted in primary care settings.