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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are often characterized by their focus on practical aspects of designing a study that include recruitment and consent, adherence and the use of routinely available equipment.

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Pragmatic is a software company offers a range of casino games for online gambling platforms. Its iGaming software is used by top operators and land based casinos. The company provides front-end tools for design, analysis, promotions, marketing, payment systems, security, customer support and bug reporting. Additionally, the company provides its players a secure environment that features high-quality graphics and games.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographic areas. This kind of heterogeneity is necessary for practical trials to be valid and helps reduce bias in the results. However, too much heterogeneity can cause issues with the design of the trial.

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Pragmatic Play has gained a reputation for offering top-quality games and an outstanding user experience. Its software is accessible on mobile devices and in a variety of languages. Despite its infancy, it has already established itself as a premier casino gaming platform. Wolves is one of the latest games that is a 5-reel slot machine that has a high RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically requested by practitioners and policymakers to help inform their decisions. They can be used to determine the causal relationship between an intervention and its effects. However, they shouldn't be used to substitute for explanatory trials.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also suggested a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial which includes the recruitment process, the design and implementation of the intervention, as well as monitoring.

There is a growing increase in the number of pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatics. It is important to remember, however, that the majority of studies were conducted in primary care settings.