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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as focusing on practical aspects of designing a study which include recruitment and consent, adherence and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from various geographical areas. This type of heterogeneity is required for pragmatic trials to be valid and reduces the chance of bias in the results. Too much heterogeneity, however can result in problems with the trial design.

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Pragmatic Play is known for its top-notch games, and for providing a superior user experience. Its software is accessible on mobile devices and in a variety of languages. Despite its relatively young age it has already established itself as a premier casino gaming platform. Wolves is one of the latest games that is a 5-reel slot machine with a healthy RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are typically requested by practitioners and policymakers in order to inform their decisions. They can also be used to determine the causal relationship between an intervention and its results. However, they shouldn't be used in lieu for explanation studies.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace or 프라그마틱 complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the elements of a practical trial which includes the recruitment process, the design and implementation of the intervention, and monitoring.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority were conducted in primary-care settings.