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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are often focused on the practical aspects of research design, like the recruitment process and consent in adherence, as well as the use of commonly available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from different geographic areas. This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also reduces the chance of bias in the results. Too much heterogeneity, however can result in problems with the trial design.
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. Usually, they are requested by practitioners and policymakers to guide their decisions. They can also be used to determine the causal relationship between an intervention and its effects. However, they shouldn't be used to substitute for explanatory trials.
The pragmatism concept is controversial and there are questions about whether pragmatic trials should replace or 프라그마틱 정품인증 complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis and pragmatic trials, which guide the policy and practice of. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic study that include the recruitment process, the design and delivery of the intervention, and monitoring.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these studies were conducted in primary-care settings.