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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are usually characterized by a focus on the practical aspects of research design, like recruitment and consent as well as adherence to the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from various geographical areas. This type of heterogeneity, which is essential for a pragmatic trial to be valid and to reduce bias in the results, is also necessary. A high degree of heterogeneity, however could cause issues with the trial design.
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The goal of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They can be used to determine the causal relationship between an intervention and 프라그마틱 슬롯버프 슬롯 체험 [https://sciencewiki.science] its results. They should not, however, be used to replace explanatory studies.
The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the elements of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, as well as monitoring.
There is a growing increase in the number pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.