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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often characterized as a focus on the practical aspects of study design, including the recruitment process and consent, adhering and the use of standard equipment.

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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for practical trials to be valid and reduces the chance of bias in the results. However too much heterogeneity could lead to issues with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. Usually, they are requested by practitioners and policymakers in order to guide their decisions. They can be used to determine the causality of an intervention with its outcomes. However, they shouldn't be used to substitute for the use of explanation studies.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis, and pragmatic trials that inform the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study which includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and 프라그마틱 슬롯버프 (Squareblogs.Net) naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatism. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.