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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are usually characterized by a focus on the practical aspects of the study design, including recruitment and consent as well as adherence to the use of commonly available equipment.
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Pragmatic, a software company provides a variety of casino games to online gambling platforms. Its iGaming software is used by the top operators and land based casinos. The company provides front-end design tools, analysis, promotions, marketing payment systems, security, customer service, and bug reporting. The company also offers security, high-quality graphics, gaming and security.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and participants from different geographical regions. This type of heterogeneity which is vital for pragmatic trials to be reliable and reduce bias in results is also essential. However too much heterogeneity could cause problems with the design of the trial.
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Legality
Pragmatic Play is known for its top-notch games, and for offering an exceptional user experience. Its software is designed to work on mobile devices and supports various languages. It has established itself as one of the top gaming platforms in the casino industry despite its relative youth. Wolves is one of the most recent releases which is a five-reel slot machine with a hefty RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. Usually, they are requested by practitioners and policymakers to help guide their decisions. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. They should not, however, be used to replace explanation studies.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study which includes recruitment, design, implementation of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to remember, however, that the majority were conducted in primary-care settings.