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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on practical aspects of the research design, like recruitment and consent, adherence, and the use of routinely available equipment.

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A practical trial that employs different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for 프라그마틱 정품인증 a pragmatic trial to be reliable and reduce bias in results, is also necessary. However excessive heterogeneity could result in issues with the design of the trial.

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The aim of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. Usually, they are requested by practitioners and policymakers to help guide their decisions. They are also a good method to determine the causality between the intervention and its effects. However, they should not be used to substitute for explanatory trials.

The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the clinical or physiological hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, as well as the follow-up.

There is a growing increase in the number pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatics. It is important to keep in mind that the majority of these trials were conducted in primary care settings.