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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are often described as a focus on the practical aspects of design, including recruitment and consent, adherence and the use routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from different geographic areas. This kind of heterogeneity is essential for 프라그마틱 정품확인방법 프라그마틱 슬롯무료 (visit the next document) practical trials to be valid, and it also reduces bias in the results. However, too much heterogeneity can result in problems with the trial design.
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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually requested by practitioners and policymakers to guide their decisions. They can also be a great method to determine the cause-effect relationship between an intervention and its outcomes. They should, however, not be used to replace the need for explanation studies.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool attempted to define the elements of a practical trial, including recruitment, design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.