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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, including recruitment and consent, adherence, and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographic areas. This type of heterogeneity that is crucial for pragmatic trials to be valid and reduce bias in results is also essential. A high degree of heterogeneity, however could cause issues with the design of the trial.

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The goal of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually requested by practitioners and policymakers to help inform their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. They should not, however be used to replace explanatory studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they are an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a practical study, including the recruitment, design, 프라그마틱 무료스핀 and delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is an indication that the health sciences community is becoming more acquaint to the issue of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.