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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized by a focus on practical aspects of the study design, including the recruitment and consent process, adherence, and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from various geographical areas. This kind of heterogeneity, that is crucial for a pragmatic trial to be reliable and 프라그마틱 공식홈페이지 무료게임 (Techdirt.Stream) lessen the chance of bias, is also necessary. However, too much heterogeneity can cause problems with the design of the trial.

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Legality

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically commissioned by policymakers and practitioners in order to guide their decisions. They can also be a great way to identify the cause-effect relationship between an intervention and its results. However, they should not be used to substitute for the use of explanation trials.

The concept of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study, including recruitment, design, implementation of the intervention and its follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs) resulted in 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.