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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually focused on practical aspects of the study design, such as the recruitment and consent process in adherence, as well as the use of standard equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, 프라그마틱 슬롯 무료 정품확인 (Https://bookmarkwuzz.com) which employed various investigators and included participants from different geographic areas. This type of heterogeneity is required for practical trials to be valid and helps to reduce bias in the results. A high degree of heterogeneity, however, can cause problems with the design of the trial.
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The aim of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They are also a good method of determining the cause-effect relationship between the intervention and its effects. They should, however, not be used to replace the need for explanation studies.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a pragmatic study which includes the recruitment process, the design and implementation of the intervention, and monitoring.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to note that the majority of these studies were conducted in primary care settings.