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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically characterized by a focus on the practical aspects of study design, including the recruitment and consent process, adherence, and the use of commonly available equipment.
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A pragmatic trial that uses various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, 프라그마틱 정품확인 that is crucial for pragmatic trials to be reliable and reduce bias in results is also essential. However excessive heterogeneity could result in problems with the design of the trial.
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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically commissioned by policymakers and practitioners in order to guide their decisions. They also provide a useful way to identify the causal relationship between an intervention and its outcomes. However, they should not be used to substitute for explanatory trials.
The idea of pragmatism is controversial, and 프라그마틱 데모 프라그마틱 체험 (via dokuwiki.stream) there are questions about whether pragmatic trials can be used to replace explanation tests or if they are an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate a physiological or clinical hypothesis and pragmatic trials, which inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study that includes recruitment, design, implementation of the intervention and follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatics. However, it is important to remember that the majority of these studies were conducted in primary care settings.