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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of designing a study that include recruitment and consent, adherence and the use of routinely available equipment.

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Pragmatic is a software company provides a variety of casino games on online gambling platforms. Pragmatic's iGaming software is used by leading operators as well as land-based casinos. The company offers front-end design tools, analysis tools, promotions, marketing and payment systems, as well as security, customer service, and bug reporting. The company also offers security, high-quality graphics, gaming and security.

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A practical trial that employs different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid and reduces the chance of bias in the results. However, too much heterogeneity could cause issues with the design of the trial.

Pragmatic Play, one of the biggest players on the live casino market, offers an array of traditional table games like Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gaming experience as well a full range of virtual betting options. The company has also developed numerous interactive game shows that make online gambling fun. Some of these shows are telecast live and some are hosted by famous personalities from the field.

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Pragmatic Play is a new player in the online casino industry however, it has already made a name for itself by offering mobile-friendly slots. Their games are optimised for mobile devices and operate on HTML5 technology. They're also endorsed by reputable gaming authorities to ensure fairness and transparency. This is a good sign for players, as it means that the games have been examined and verified to make sure that the results of each round are fair and impartial.

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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can also be used to assess the causality of an intervention and its results. However, they shouldn't be used in lieu for explanation trials.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also suggested a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a pragmatic study that include recruitment, design and delivery of the intervention, and follow-up.

There is a positive increase in the number of pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health science community is becoming more sensitive to the issue of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.