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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically described as a focus on the practical aspects of design that include recruitment and consent, adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and participants from various geographical areas. This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity and reduces the chance of bias in the results. A high degree of heterogeneity, however can result in problems with the design of the trial.

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Pragmatic trials seek to replicate real-world situations and have the highest external validity. Usually, they are requested by practitioners and policymakers in order to inform their decisions. They can also be used to determine the causal relationship between an intervention with its outcomes. However, they should not be used in lieu for 프라그마틱 무료게임 the use of explanation studies.

The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study which includes recruitment, design, implementation of the intervention and its follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority were conducted in primary care settings.