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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically characterized by a focus on practical aspects of the study design, including the recruitment and consent process in adherence, as well as the use of routinely available equipment.

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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be valid and also reduces the chance of bias in the results. Too much heterogeneity, however could cause issues with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are usually commissioned by policymakers and practitioners to guide their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. They should, however, not, 프라그마틱 데모 슬롯 [Shadowxcraft.net] be used to replace the need for explanation studies.

The pragmatism concept is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a practical trial that include recruitment, design and delivery of the intervention, as well as the follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.