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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are usually focused on the practical aspects of the research design, like the recruitment and consent process, adherence, and the use of standard equipment.
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Pragmatic is a software developer that offers a broad range of casino games on online gambling platforms. Pragmatic's iGaming solutions are used by the most reputable operators as well as land-based casinos. The company offers front-end design tools, analysis, marketing, promotions, payment systems, security, customer service and bug reporting. The company also offers a safe environment with high-quality graphics, gaming and security.
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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be able to prove their validity and helps to reduce bias in the results. Too much heterogeneity, however can result in problems with the design of the trial.
Pragmatic Play is also a major player on the live casino market, providing an array of table games that are classic such as Blackjack and Roulette in various variations. The live studios of the company in Romania and Malta provide customers with an authentic gaming experience and a wide range of virtual betting options. The company has also developed various interactive games to make online gambling enjoyable. Some of these shows feature live hosts, while others are hosted by celebrities from the industry.
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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. They are usually commissioned by policymakers and practitioners in order to inform their decisions. They can be used to determine the causality of an intervention and its effects. They should, however, not, be used to replace explanation studies.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study that includes recruitment, design, implementation of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.