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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of study design, including the recruitment process and consent, adhering and the use of standard equipment.
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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be valid and reduce bias in results, is also necessary. However, too much heterogeneity, can cause problems with the trial design.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by policymakers and practitioners in order to guide their decisions. They can also be used to assess the cause-effect relationship of an intervention with its outcomes. However, they should not be used to substitute for explanatory studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the validity of a clinical or physiological hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the elements of a practical study which includes recruitment, design, implementation of the intervention and 프라그마틱 슬롯 사이트 its follow-up.
There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.