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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are typically described by their focus on practical aspects of study design which include recruitment and consent, adherence and the use of standard equipment.
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A pragmatic trial that uses different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and 프라그마틱 정품확인 플레이 (https://socialbookmarkgs.com/) also helps to reduce the chance of bias in the results. However too much heterogeneity could result in issues with the design of the trial.
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The aim of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. Usually, they are commissioned by policymakers and practitioners in order to inform their decisions. They can also be used to determine the causality of an intervention and its results. However, they shouldn't be used in lieu for the use of explanation trials.
The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a pragmatic study which includes the recruitment process, the design and implementation of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary-care settings.