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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described as a focus on the practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and participants from different geographical regions. This kind of heterogeneity is necessary for 프라그마틱 정품 사이트; http://www.1v34.Com/space-uid-530617.html, pragmatic trials to be able to prove their validity, and it also helps reduce the chance of bias in the results. However too much heterogeneity could lead to problems with the design of the trial.
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The purpose of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. Usually, they are commissioned by policymakers and practitioners to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention and its effects. However, they should not be used to substitute for the use of explanation trials.
The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study, including the recruitment, design, and delivery of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.