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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of study design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographic areas. This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity, and it also reduces bias in the results. However, too much heterogeneity can lead to problems with the design of the trial.
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The aim of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. They are usually requested by practitioners and policymakers in order to inform their decisions. They can also be a great way to identify the cause-effect relationship between an intervention and its results. They should, however, not be used to replace the need for explanation studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace tests for explanations or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis and pragmatic trials, which guide policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study, including recruitment, design, 프라그마틱 순위 홈페이지 (Https://www.ddhszz.Com) implementation of the intervention and follow-up.
The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.