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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are typically described as focusing on practical aspects of designing a study, including recruitment and consent, adherence and the use routinely available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for a pragmatic trial to be valid and to reduce bias in the results is also essential. However, too much heterogeneity can lead to issues with the design of the trial.
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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. Usually, they are requested by practitioners and policymakers to guide their decisions. They can also be a great way to identify the cause-effect relationship between the intervention and its effects. However, they should not be used in lieu for the use of explanation studies.
The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and 프라그마틱 이미지 Lellouch1 suggested the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study which includes the recruitment, design, and delivery of the intervention and follow-up.
There is a positive trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) produced 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more sensitive to the issue of pragmatics. It is important to keep in mind that the majority of these trials were conducted in primary care settings.