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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often focused on the practical aspects of study design, such as the recruitment and consent process as well as adherence to the use of routinely available equipment.

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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for practical trials to be valid, and it also helps reduce bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.

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Legality

Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is accessible on mobile devices and in multiple languages. It has established itself as one of the most popular gaming platforms in the casino industry despite its relatively young age. Its latest releases include Wolves, a 5-reel video slot with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. Usually, they are commissioned by policymakers and practitioners in order to inform their decisions. They can also be used to determine the causal relationship between an intervention and its effects. However, they should not be used to substitute for the use of explanation studies.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which confirm the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a pragmatic trial that include the recruitment process, the design and delivery of the intervention, and monitoring.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more sensitive to the subject of pragmatics. It is important to keep in mind that the majority of these studies were conducted in primary care settings.