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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized by a focus on the practical aspects of the study design, such as recruitment and consent as well as adherence to the use of standard equipment.
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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However excessive heterogeneity could lead to issues with the design of the trial.
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The purpose of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. Usually, they are ordered by policymakers and practitioners to inform their decisions. They are also a good method of determining the causal relationship between the intervention and its effects. However, they should not, be used to replace explanation studies.
The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the clinical or physiological hypothesis as well as pragmatic trials, which guide the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study, 프라그마틱 공식홈페이지 including the recruitment, design, and delivery of the intervention and 프라그마틱 슬롯 무료체험 follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatism. It is important to note, however, that the majority of studies were conducted in primary care settings.