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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of designing a study, including recruitment and consent, adherence and the use of standard equipment.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be valid and to reduce bias in the results is also essential. However too much heterogeneity could cause problems with the design of the trial.

Pragmatic Play is also a major player on the live casino market, offering an array of table games like as Blackjack and Roulette in various variations. The live studios of the company in Romania and Malta provide a genuine gambling experience for players and offer an extensive selection of virtual betting options. The company also has several game shows which make online gambling fun and interactive. Some of these shows feature live hosts, whereas others are hosted by famous personalities from the industry.

Mobile compatibility

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Pragmatic Play offers not only mobile-friendly slot machines but also table games and live casino. Pragmatic Play is licensed and is regulated by various governing bodies that include the Malta Gaming Authority and UK Gambling Commission. The games of the company are secured with high-end encryption and its security team is on hand to help players with any issues.

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Legality

Pragmatic Play has earned a name for itself by providing top-quality games and an outstanding user experience. Its software is accessible on mobile devices and in multiple languages. Despite its infancy it has already established itself as a leading casino gaming platform. Wolves is one of the most recent releases that is a 5-reel slot machine with a healthy RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically requested by practitioners and policymakers to inform their decisions. They can be used to determine the cause-effect relationship of an intervention and 프라그마틱 무료체험 its effects. However, they should not be used to replace explanation studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they are an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study, including recruitment, design, implementation of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.