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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are typically described as a focus on the practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographic areas. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. However excessive heterogeneity could cause issues with the design of the trial.

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Mobile compatibility

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Legality

Pragmatic Play is known for its top-quality games and for offering an exceptional user experience. The software is available on mobile devices as well as in various languages. Despite its relative youth, it has already established itself as a leading gaming platform for casinos. The latest releases include Wolves, a 5-reel video slot with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to determine the causal relationship between an intervention with its outcomes. However, they shouldn't be used as a substitute for explanatory studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or 프라그마틱 슈가러쉬 physiological hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study that includes the recruitment, design, and delivery of the intervention and follow-up.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to note that the majority of these studies were conducted in primary care settings.