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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of study design that include the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and 프라그마틱 홈페이지 participants from various geographical areas. This type of heterogeneity, which is essential for a pragmatic trial to be reliable and reduce bias in results, is also necessary. However, too much heterogeneity can result in problems with the design of the trial.

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The purpose of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are usually requested by practitioners and policy makers to inform their decision making. They also provide a useful method to determine the causal relationship between an intervention and 프라그마틱 정품 its results. However, they should not be used in lieu for explanation trials.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study, including recruitment, design, delivery of the intervention and its follow-up.

There is a positive increase in the number pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind, however, that the majority were conducted in primary-care settings.