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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of design which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from different geographic areas. This kind of heterogeneity is required for practical trials to be valid, and it also helps to reduce bias in the results. However, too much heterogeneity could cause issues with the design of the trial.

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Legality

Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. Its software can be used on mobile devices and in a variety of languages. Despite its infancy, it has already established itself as a premier gaming platform for casinos. The most recent releases include Wolves, a 5-reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to mimic real-life scenarios and to achieve maximum credibility externally. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to assess the causal relationship between an intervention and its results. They should, however, not, be used to replace explanatory studies.

The concept of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate a physiological or clinical hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study, including recruitment, design, delivery of the intervention and its follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.