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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized by a focus on the practical aspects of research design, like the recruitment process and consent in adherence, as well as the use of routinely available equipment.
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A pragmatic study that involves various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity, and 프라그마틱 슬롯무료 it also helps reduce the chance of bias in the results. Too much heterogeneity, however could cause issues with the design of the trial.
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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually requested by policy makers and practitioners to inform their decision making. They also provide a useful way to identify the causality between an intervention and its outcomes. They should not, however be used to replace explanatory studies.
The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study which includes the recruitment, design, and delivery of the intervention and its follow-up.
There is a growing increase in the number of pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatics. It is important to remember, however, that the majority of studies were conducted in primary-care settings.