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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically characterized by a focus on practical aspects of the study design, such as recruitment and consent in adherence, as well as the use of commonly available equipment.

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Pragmatic is a software developer that provides a variety of casino games for online gambling platforms. Its iGaming solutions are used by the top operators and land-based casinos. The company offers front-end design tools, analysis tools, promotions, marketing payment systems, security, customer service and bug reporting. Additionally, the company provides its players a safe and secure environment with high-quality graphics as well as gameplay.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from different geographic areas. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and helps to reduce the chance of bias in the results. However excessive heterogeneity could result in problems with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They can also be a great method to determine the cause-effect relationship between an intervention and its results. However, they shouldn't be used to substitute for explanatory studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials, which guide the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study which includes recruitment, design, delivery of the intervention and its follow-up.

There is a positive increase in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.