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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of design which include recruitment and consent, adherence and the use of routinely available equipment.

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A pragmatic study that involves various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid, and it also helps to reduce the chance of bias in the results. A high degree of heterogeneity, however, can cause problems with the design of the trial.

Pragmatic Play, a major player on the live casino market offers a variety of classic table games such as Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic experience in gambling as well a full range of virtual betting options. The company has also developed numerous interactive game shows that make gambling online enjoyable. Some of these shows have a live host, while others are hosted by prominent personalities from the industry.

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Pragmatic Play offers not only mobile-friendly slot machines but also tables games and live casinos. Pragmatic Play is licensed and is regulated by various governing bodies which include the Malta Gaming Authority and UK Gambling Commission. The games are supported by the latest encryption technology and the security team is always on hand to help players solve any issues they might have.

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Legality

Pragmatic Play is known for its top-notch games, and also for providing an outstanding user experience. Its software can be used on mobile devices and in a variety of languages. It has earned itself the status of one of the leading gaming platforms for casinos despite its relative infancy. Wolves is one of the most recent releases that is a 5-reel slot machine with a hefty RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are usually commissioned by practitioners and policy makers to inform their decision making. They can also be a great method of determining the cause-effect relationship between the intervention and its effects. However, they shouldn't be used in lieu for the use of explanation trials.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can be used to replace explanation tests or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis and pragmatic trials that inform the policy and practice of. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the elements of a pragmatic study which includes recruitment, design and delivery of the intervention, as well as follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.