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Pragmatic trials are studies designed to inform the real-world practice of clinical. They are typically characterized by a focus on practical aspects of the research design, like recruitment and consent, adherence, and the use of routinely available equipment.
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A practical trial that employs a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. Too much heterogeneity, however, can cause problems with the design of the trial.
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Pragmatic Play, a relatively new player in the world of online casinos, has gained recognition for its mobile-friendly slot machines. Their games are optimized for mobile devices and run on HTML5 technology. They are also certified by trusted gaming authorities to ensure fairness and transparency. This is a positive indicator for players, since it means that the games are checked and verified to ensure that the results of every round are random and fair.
Pragmatic Play offers not only mobile-friendly slot machines, but also tables games and live casinos. The company is licensed and is regulated by various regulatory bodies, including the Malta Gaming Authority and UK Gambling Commission. The company's games are protected by high-end encryption and its security staff is available to assist players in any situation.
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Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. The software is available on mobile devices and in multiple languages. Despite its infancy it has already established itself as a premier gaming platform for casinos. The latest releases include Wolves, a 5-reel video slot with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
The goal of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are typically commissioned by practitioners and policy makers to guide their decision-making. They also provide a useful way to identify the causal relationship between an intervention and its outcomes. However, they shouldn't be used to substitute for the use of explanation trials.
The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a practical study that includes recruitment, design, delivery of the intervention and its follow-up.
There is a positive increase in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.