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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are often characterized by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and participants from various geographical areas. This type of heterogeneity is necessary for pragmatic trials to be valid, and it also helps reduce the chance of bias in the results. However too much heterogeneity could cause problems with the design of the trial.

Pragmatic Play is also a major player on the live casino market, providing an array of table games like as Blackjack and Roulette in various variations. Pragmatic Play's live studios in Romania and Malta offer a real-life gambling experience for customers and offer an extensive selection of virtual betting options. The company also hosts a variety of game shows that make online gambling exciting and interactive. Some of these shows have a live host, while others are hosted by famous personalities from the industry.

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Pragmatic Play offers not only mobile-friendly slot machines as well as live casino and table games. Pragmatic Play is licensed and regulated by a variety of regulatory bodies, including the Malta Gaming Authority and UK Gambling Commission. The games offered by the company are protected by high-end encryption and its security team is on hand to assist players with any issues.

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Pragmatic Play offers a large number of games you can play for free before you decide whether you want to purchase them. These free games can be played on any device including tablets, desktops and smartphones. They're easy to navigate and you can play them from anywhere with an internet connection. Some Pragmatic Play sites even allow you to test your luck on the go with the practice mode. This helps you get familiar with the game rules and features before playing for real money.

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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. Usually, they are ordered by policymakers and practitioners to guide their decisions. They are also a good method of determining the causal relationship between the intervention and its effects. They should, however, not be used to replace explanation studies.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study which includes recruitment, design, delivery of the intervention and follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to note, however, that the majority of studies were conducted in primary-care settings.