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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are often described by their focus on practical aspects of study design that include recruitment and consent, adherence and the use routinely available equipment.
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A practical trial that employs a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for practical trials to be valid and also helps reduce the chance of bias in the results. However too much heterogeneity could cause issues with the design of the trial.
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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. They are usually requested by practitioners and policy makers to guide their decision-making. They are also a good method to determine the cause-effect relationship between an intervention and its outcomes. However, they shouldn't be used to substitute for 프라그마틱 추천 explanation trials.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, 프라그마틱 슬롯 (http://delphi.larsbo.org/User/windowgauge61) which validate the clinical or physiological hypothesis and pragmatic trials that inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the elements of a pragmatic research study, including recruitment, design, implementation of the intervention and its follow-up.
There is a growing increase in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and 프라그마틱 정품 확인법 naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health science community is becoming more sensitive to the subject of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary care settings.