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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically described as a focus on the practical aspects of designing a study that include the recruitment process and consent, adhering and the use of routinely available equipment.

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Pragmatic Software, a software firm, offers a variety of casino games for online gambling platforms. Its iGaming software is used by leading operators as well as land-based casinos. The company offers front-end site design tools, analysis tools and marketing, promotions security payment systems, customer service and bug-reporting. Additionally, the company offers its users a safe environment that features high-quality graphics and gaming.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and had participants from different geographical regions. This type of heterogeneity, which is vital for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However excessive heterogeneity could result in issues with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. They are typically commissioned by policymakers and practitioners to help guide their decisions. They can be used to determine the causality of an intervention and its results. However, they should not be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which confirm the validity of a physiological or clinical hypothesis, 슬롯 and pragmatic trials, that inform policy and practice decision-making. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a practical trial which includes recruitment, design and delivery of the intervention, and the follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health science community is becoming more sensitive to the subject of pragmatic thinking. It is important to note that the majority of these trials were conducted in primary care settings.