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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are typically described as focusing on practical aspects of design, including recruitment and consent, 프라그마틱 정품 사이트 adherence and the use routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographical regions. This kind of heterogeneity is required for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. Too much heterogeneity, however could cause issues with the design of the trial.
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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually requested by practitioners and policymakers in order to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention and its effects. However, they should not be used in lieu for the use of explanation trials.
The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the clinical or physiological hypothesis and pragmatic trials that inform the policy and practice of. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic study which includes recruitment, design and delivery of the intervention, and monitoring.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.